Molecular hydrogen studies, trials and scientific publications

Introduction
Hydrogen crash courses
Human studies
Relevant diagrams and images
Hydrogen research by organ or disease name
Publications
Web links

Introduction

Molecular hydrogen is being studied intensely in Asia by Scientists, MDs and PhDs. There are over 600 studies published. Hydrogen helps with over 166 human identified conditions. It has been shown to be safe for everyone, as the body makes it naturally every day in the intestines. The clinical studies are mostly reported from Japan, Korea and China, the three countries that are actively funding molecular hydrogen research.

Hydrogen gas has no cytotoxicity, even at high concentrations. The safety of H₂ for humans is demonstrated by its application in Hydreliox, an exotic breathing gas with a mixture of 49% H2, 50% helium and 1% O2, which is used to prevent decompression sickness and nitrogen narcosis during very deep technical diving. ( 1 ) With Hydreliox in their tanks, scuba divers can safely pursue diving depths of up to four hundred feet.

Hydrogen water has lots of not understood properties. The absolute tiniest concentration dissolved in water has still statistical significant effects. Notably, H2 concentrations as low as 0.08 ppm exhibited nearly the same effects as saturated Hydrogen water with (1.5 ppm). Therefore, the amount of administered H2 seems to be independent of the magnitude of effects in many cases.

We need to know how to optimize H2 dose, timing, and delivery methods. Nevertheless, for H2 treatment, promising applications are emerging for many human diseases, and personalized treatments for patients are a therapeutic goal. Thus, appropriately designed for large-scale, prospective clinical studies are warranted.

The positive effects of H₂ have been observed in practically all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants. A predominance of oxidative stress-mediated diseases and inflammatory diseases has been observed.

A successful drug has to be easily available, diffuse rapidly, act on multiple pathological intertwined mechanisms and have few side effects. Hydrogen is all that.

Human Studies that are in the process of clinical trials and that have shown beneficial reactions are done on Cancer, Exercise, Inflammation, Kidney, Metabolism, Muscle, Nervous System, Skin, type 2 Diabetes, Cerebral Ischemia, Rheumatoid Arthritis and Parkinson’s Disease. ( 12 )
Animal Studies that have shown beneficial reactions are done on Cancer, Cardio vascular, Eye and Ear, Gut, Inflammation. Kidney, Liver, Lung and Metabolism. ( 13 )
In Vitro Studies that have shown beneficial reactions are done on Wound healing, Mitochondrial inflammations, Radical scavenging, Improved Blood fluidity, Lymphocyte protection against ionizing radiation, inflammation inhibition in retinal microglia cells, attenuates fatty acid uptake and lipid accumulation and inhibits the growth of human tongue carcinoma cells. ( 14 )

Hydrogen Science "crash courses"

These publications are very instructive because they summarize all current and past studies on Hydrogen.

2011: Dr. Shigeo Ohta reports at nih.gov: ( He is the Master ! )

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2016: Dr. Gart L. Nicholson reports on 338 publications studying the benefits of molecular hydrogen at scirp.org:

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2017: Li Ge, Li Ming Yang, Na-Na Yang, Xin-Xin Yin and Wen-Gang Song report in another very detailed summary at oncotarget.com:

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Click any of the links above and search in the opening document for the medical term you are interested in.

Tip: You will find bracketed numbers like this [3] all over in these documents. Clicking them will show the url of the original publication at the bottom of the document.

Human studies with hydrogen

The most common argument of critics is that the scientific studies are done only in vitro and with animals. Nothing could be further from the truth. There are each year more studies and trials done with humans. A revolution in remedial and preventive medicine is coming.

60 completed and published human studies [ 15 ]

Another 25 registered, but still running human studies [ 16 ]

This hydrogen inhalation therapy is the first full-scale clinical trial in the world to confirm the effectiveness performed by the Japanese Ministry of Health, Labor and Welfare after being certified as advanced medical technology. A multi institution, double blind, human clinical trial: Efficacy of inhaled hydrogen gas therapy for patients after out-of-hospital cardiac arrest [17] [Google translation]

Tip: Sometimes, when the content is just the abstract, you have to look for the full article at the bottom of the opening page.

Diagrams and Images click images to enlarge

The science behind Hydrogen

Antioxidant sizes

Number of publications 2014

Hydrogen saturation levels

Endogenous antioxidants

Pathways of Hydrogen

Radical formation

H₂ flammability vs other gases

H₂ concentrations in healing springs

Chronic Inflammatory Diseases

Oxygen removal pathways

Scope of diseases

Hydrogen variants

Hydrogen affected areas

Listings by organ or disease name

The scope of all research done since 2007 covers nearly every disease known.

Reviewing the three lists below and considering the non-toxicity and benign nature of Hydrogen, it is possible to experiment in any direction. The trend in all reports is towards homeostasis.